SMARCB1 (INI-1)-deficient Sinonasal Carcinoma

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SMARCB1(INI1)-deficient Sinonasal Basaloid Carcinoma

Poorly differentiated sinonasal carcinomas are a heterogenous group of aggressive neoplasms that encompasses squamous cell carcinoma including basaloid variant, lymphoepithelial carcinoma, sinonasal undifferentiated carcinoma, and neuroendocrine-type small cell carcinoma. We herein describe 3 cases of a hitherto unreported variant combining features of basaloid carcinoma with variable interming...

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SMARCB1 (INI1)-deficient sinonasal carcinoma: a newly described entity

SMARCB1 (INI1)-deficient sinonasal carcinoma is a recently described variant of sinonasal tract carcinoma characterized by complete loss of nuclear SMARCB1 (INI1). It is very rare and currently underdiagnosed because of a lack of awareness. Before the description of SMARCB1 (INI1)-deficient sinonasal carcinomas, these tumors were probably misclassified as various malignant neoplasms. To date, o...

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Sinonasal undifferentiated carcinoma.

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Oncogenic roles of SMARCB1/INI1 and its deficient tumors

SMARCB1/INI1 is one of the core subunit proteins of the ATP-dependent SWI/SNF chromatin remodeling complex, and is identified as a potent and bona fide tumor suppressor. Interactions have been demonstrated between SMARCB1/INI1 and key proteins in various pathways related to tumor proliferation and progression: the p16-RB pathway, WNT signaling pathway, sonic hedgehog signaling pathway and Polyc...

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Sinonasal undifferentiated carcinoma: an update.

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ژورنال

عنوان ژورنال: American Journal of Surgical Pathology

سال: 2017

ISSN: 0147-5185

DOI: 10.1097/pas.0000000000000797